Mike Smith Fan Mail Address:

Mike Smith
Mary Collins Agency, Inc.
4131 N. Central Expressway
Suite 900
Dallas, TX 75204
USA

Address info:

Mary Collins Agency, Inc.
(Talent Agency)
4131 N. Central Expressway
Suite 900
Dallas, TX 75204
USA

Mike Smith Biography:

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Michael Smith, a Canadian scientist of British ancestry, earned the 1993 Nobel Prize in Chemistry for his work pioneering oligonucleotide-based site-directed mutagenesis, a method that allows researchers to make targeted changes to genes and the proteins they code for. Researchers have used site-directed mutagenesis to investigate the structural and functional relationships between proteins involved in the pathophysiology of Alzheimer’s disease, as well as to test the viability of gene therapy approaches for cystic fibrosis, sickle cell disease, and hemophilia, to characterize protein receptors at neurotransmitter binding sites, to design analogs with novel pharmaceutical properties, to study viral proteins involved in viral replication, and to determine the characteristics of protein receptors at neurotransmitter binding sites.

During the early 1970s, Smith had the idea for site-directed mutagenesis and spent the next several years perfecting it. Scientists now have a novel approach to investigating protein function. The function of a protein is determined by its three-dimensional structure, which is formed from long chains of amino acids. The sequence of nucleotides that make up a gene encodes the amino acid sequence of the protein that is encoded by that gene. Mutations in the gene’s nucleotide sequence may be used to alter the protein’s amino-acid sequence and, by extension, its function. Producing a modified version of a protein allows researchers to examine how it differs from the original in terms of structure and function.

However, before the development of Smith’s method, biochemical researchers relied on a clumsy and time-consuming procedure that was prone to error: random mutations. Smith invented site-directed mutagenesis to fix this issue, which allows for modifying nucleotide sequences at precise, predetermined positions inside a gene. This has allowed scientists to learn how each amino acid affects protein structure and function. Site-directed mutagenesis has various practical uses in fields such as health, agriculture, and industry, in addition to its importance in fundamental research. As an example, it may be used to generate a version of a protein with enhanced stability, activity, or practicality compared to the native protein.

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